Source One is a consulting services company and we’re currently looking for the following individual to work as a consultant with our direct client, a global pharmaceutical manufacturing client in La Jolla, CA.
This role will be onsite and available to candidates local to the La Jolla, CA area. We are interested in every qualified candidate who is eligible to work in the United States. Unfortunately, we are not able to sponsor visas or employ corp-to-corp
Title: Scientist II Research & Development (Oligonucleotide Analytics)
Location: La Jolla, CA
Onsite (Mon-Fri, 40 hours)
Contract Duration: 12 months, with likely extension
Pay Rate: $52.26 per hour (w2)
Key Responsibilities:
30% • Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
20% • Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis
10% • Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
20% • Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
5% • Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
• Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
• Support integrity confirmation requests (such as concentration) by assay development and biology teams
3% • Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
5% • Ensure the supply of laboratory consumables and reagents are in stock as needed
• Maintain a high level of productivity in the laboratory setting.
2% • Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
• Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
• Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
Role is 100% onsite
Job Summary Under the general direction of the Director CDI/Coding or designee, the Medical Records Coder I will improve documentation, data quality and revenue cycle operations. The coder assigns International Classification of Disease system- 10 (ICD), CM, and PCS...
...overall body of software development knowledge, including solution options, risk, cost, and impacts. Mentor junior developers help them grow their experience and knowledge. Participate actively in code reviews, tool evaluations, documenting new features. Partner...
...extension) Location: Durham, NC 27712 Job Summary: Provide routine support & troubleshooting for the batch & documentation review process in production operations. Ensure that batch documentation as well as SOPs & other standardized documentation from...
...Shape the Future of Aesthetic Excellence Plastic Surgeon Opportunity in Columbus, GA Job#16699683A premier cosmetic and reconstructive surgery center in western Georgia is seeking a skilled and passionate Plastic Surgeon to join a high-performing team. Services include...
...controllers. Configuration and repair maintenance on DCS and PLC systems. Must Haves: ~4+ years of experience as a calibration technician ~ Experience working in manufacturing or large scale equipment (size of a semi truck for comparison)~ Strong Knowledge of...